| abstract |
A compound of formula (I) wherein A1 is NH or CH2; R is H or C1-6alkyl; R3 is C1-6alkyl, Ar-C1-6alkyl, C3-7cycloalkylC1-6alkyl, or Het-C1-6alkyl, R6 is 4-almidino-Ar-CON(CH3), 2(4-piperdinyl)(N-methyl)ethylaminocarbonyl, 4-(4-piperidinyl)piperidinylcarbonyl, 4-((2-amino)ethyl)-piperidinylcarbonyl, 3-(4-piperidinyl)(N-methyl)propylaminocarbonyl, 4-(4-pyridyl)piperidinylcarbonyl, 2-(4-piperidinyl)ethylcarbonylamino, 2-(4-piperidinyl)ethylcarbonyl(N-methyl)amino, or (1,2,3,4-tetrahydro-7-isoquinolinyl)aminocarbonyl; and X is H; wherein Ar is phenyl and Het is sulfur-containing heterocycle. |