http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-419377-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1996-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd42cc030af19bfe9b4b8e4d9c3db39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_481bf8b36107aef259453cde173fd0e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec6953aa7f3075fd4c1fa4c81210ef8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf6da3025af5623fc55d0fb2e2345c66 |
| publicationDate | 2001-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-419377-B |
| titleOfInvention | Methods for the preparation of manomeric calicheamicin derivative/carrier conjugates |
| abstract | A method is provided for preparing monomeric calicheamicin derivative/carrier conjugates with higher drug loading/yield and decreased aggregation. These conjugates are prepared by incubating a calicheamicin derivative and a proteinaceous carrier in a solution comprising a non-nucleophilic, protein-compatible, buffered solution, a cosolvent selected from the group consisting of propylene glycol, ethanol, DMSO, and combinations thereof, and an additive comprising at least one C6-C18 carboxylic acid having a pH in the range from about 4.0 to 8.5 and at a temperature ranging from about 25 DEG C to about 37 DEG C for a period of time ranging from about 15 minutes to about 24 hours, and recovering monomeric calicheamicin derivative/carrier conjugates. Alternatively, the conjugates can be prepared by incubating the calicheamicin derivative and a proteinaceous carrier in a solution comprising a non-nucleophilic, protein-compatible, buffered solution and a cosolvent comprising t-butanol. |
| priorityDate | 1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.