http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-418202-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1470af2d007afa44390c8c9cfbaff5f1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 1997-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b7adf7dd6e7fde5f0e5cf9aa048f5a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87220ad3fdd8cc2d4f0e059dde60a89c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6559044dc6f2cf874e96771f6297781a |
| publicationDate | 2001-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-418202-B |
| titleOfInvention | Preparation Process for Beno [5,6] Cycloheptapyridine Derivative |
| abstract | This invention provides a preparation process for Beno [5,6] Cycloheptapyidine derivative (I), in which X represents halogen. The preparation process includes a two-step acid-base extraction and a six-step reaction, which includes (a) cyanide group protection, (b) addition reaction, (c) cyanide group regeneration, (d) Grignard reaction, (e) acid catalytic close-ring reaction, and (f) substitution reaction. The first 4 reactions (a-d) convert the reactant, 2-cyano-3-picoline, into compound (II). In reaction (e), compound (II) reacts with polyphosphoric acid under 140-170 degree C and coverts into compound (I). Finally, compound (I) converts into the product, Loratadine, in substitution reaction (f). Further more, the 2-step acid-base extraction substantially increases the yield of compound. In the first step, the product mixture (I) of reaction (e), by a base aqueous, is adjusted to around pH 6-7. Then the organic layer of the mixture is separated from the mixture. In the second step, the organic liquid, by another base aqueous, is again adjusted to around pH10-12. |
| priorityDate | 1997-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.