| abstract |
The present invention relates to 1,2-disubstituted benzamide derivatives of the following formula (I) or a salt thereof: [wherein one of A and B represents R1 (R1 is C10-30hydrocarbyl group), the other represents -(CH2)n-NR2R3, Z represents a group of formula -OCONR6-; R2 and R3 represent a hydrogen atom or a C1-6 alkyl group; or NR2R3 represents a morpholinyl group, an imidazolyl group or a piperazinyl group which may be substituted by C1-6 alkyl group or hycroxy-C1-6 alkyl group; R2 represents a hydrogen atom or a C1-6 alkyl group when A represents -(CH2)n-NR2R3 or -Z-B represents -OCONR6-(CH2)n-NR2R3; or R3 and R5 or R6 may together form a 6-to 7-member heterocycle ring containing two nitrogen atoms; R4 represents a C1-4 alkoxyl group, and R5 and R6 represent a hydrogen atom; l is an integer of 0 to 2; m is 0 or 1; n is an integer of 0 to 3]. The 1, 2-disubstituted benzamide derivatives and a salt thereof has an excellent activity for promoting the growth of hair and is useful for preventing, ameliorating and treating an alopecia of mammal animal especially human. |