| abstract |
An improved process, and intermediates, for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide (I). Compound I is useful in the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-(1H-[1,2,4-triazol-3-ylmethyl)]-(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide (II) which is useful as an inhibitor of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion, and which are accordingly useful for the prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and related diseases. A compound of the formula A-CHR1R2 wherein A is a group of the formula (XII), and R1 is H; R2 is -CH2-NH2; or R1 and R2 together form an =0 or =CH-NO2 group. |