| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634715a790f7ef0163a61e9f364bebcd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-30 |
| filingDate |
1997-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c91aec4ed908ee4d4b9a1e1566f4717
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d94872c697cceae321e98f9f79712d7 |
| publicationDate |
2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-412513-B |
| titleOfInvention |
New manufacturing process of metoprolol |
| abstract |
A method for the manufacture of metoprolol, characterized by reacting in a first step p-(2-methoxyethyl)phenol and epichlorohydrin in water as solvent during the addition of sodium or potassium hydroxide and at a temperature of 50 to 70 DEG C, evaporating the excess of epichlorohydrin and then distilling the obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)-benzene under reduced pressure, and in a second step reacting the obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)-benzene and isopropylamine is the presence of isopropyl alcohol to form metoprolol base. |
| priorityDate |
1996-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |