| abstract |
The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester comprising C1-6 alkyl or C1-6 alkenyl thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and are selected form hydrogen, halo, cyano, C1-4 alkyl, nitro, hydroxy, carboxy, C1-4 alkoxy, C1-4 alkoxycarbonyl, aminosulphonyl, C1-4 alkylaminosulphonyl, di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4 alkylcarbamoyl, di-C1-4-alkylcarbamoryl, trifluoromethyl, sulphonic acid, amino, C1-4 alkylamino, di-C1-4 alkylamino, C1-4 alkanoylamino, C1-4 alkanoyl (N-C1-4alkyl) amino, C1-4 alkanesulphonamido and C1-4 alkylS(O)n-wherein n is zero, one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to -NR3-. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. |