| abstract |
This invention relates to a kind of oxazole heterocyclic aromatic compounds as general formula (I) and the pharmaceutical composition : [in the formula, R1 is a R3-toxylate substituted by R5 and R6 where R3 is a C1-4 alkyl group or amine group; R5 is a fluorine atom; R6 is a hydrogen atom or fluorine atom; R is a C5-7 cyclic-alkylating group, 4- fluoro phenyl group or a thiophenyl group which could be replaced by a C1-4 alkyl group ; R2 is a C1-4 alkyl group]. Such oxazole heterocyclic aromatic compounds and the pharmaceutical compositions are expected to have the function of defervescence, pain-killing as well as anti-inflammation and especially to selectively inhibit cyclooxygenase COX-2 as well as minimize the side-effect of GI tract hindrance. |