| abstract |
This invention is concerned with the compounds of the formula I: in which R1 to R5 are as definitions in the claim 1. These compounds are applied in the treatment of the phthological changes related to CRF. The compounds of the formula I: wherein R1 represents C1-4 alkyl group; R2 represents the primidine replaced by two groups composeing an alkyl group of 1-4 carbon atoms and halogens and a phenyl group replaced by 1-3 the same or different groups of (C1-4) alkylgroup, halogens, (C1-4) alkyloxyl group, (C1-4) extended or branched alkyl group-OH, trifluoro (C1-4) alkylgroup; R3 represents (C1-C4) alkyl group or (C1-4) extended or branched group-O-A wherein A is, H or CO-(C1-4) alkyl group; R4 represents, (C1-4)alkyl- S-, (C1-4) alkyl group or (C1-C4) alkyl- O-B group, wherein B is -OH, -CO-(C1-4) alkylgroup, (C2-4) alkyl -OH, (C1-4)alkenyl)-O-(C1-4)alkyl group, (C1-4) alkyl group or (C1-4) extended alkyl-methylcyclopropanyl group; R5 represents -O-(C1-4) alkyl primidine group or the primidine group is replaced by (C1-4) extended alkyl OH, D represents a hydrogen or (C1-4) alkyl group; and -E represents (C1-4) extended alkyl OH, (C1-4) alkyl -OCO- (C1-4) alkyl group, (C1-4) alkyl bromide, CH(OH)-(C1-4) alkyl group, (OH)C-(C1-4)alkyl)2-, (C1-4) extended alkyl -O-SO3H, (C1-4) extended -O-(C1-4) alkyl group, -F, (C1-C4) alkoxyl group, (C1-C4) alkyl group or trifluoro (C1-4) alkyl group or H, its stereoisomers and the additive salts. |