http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-397832-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D463-00 |
| filingDate | 1995-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92784d205a17da2ae626a7aebb62252a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_033f175937882d6b6bacfb34695a95bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f97765d8c0c40bdbd18a7e9e7a6dd7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02eadb7dd685b522cf7ff0db7298fa9 |
| publicationDate | 2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-397832-B |
| titleOfInvention | Beta-Lactams |
| abstract | Beta-Lactams are described, namely of the general formula in which Z signifies methylene, oxygen or sulphur and R signifies hydrogen, lower (cyclo) alkyl optionally substituted by carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, phenylcarbamoyl or hydroxyphenyl-carbamoyl, lower alkenylmethyl, lower alkenylmethoxy-carbonyl, formyl, lower (cyclo) alkanoyl or (cyclo) alkylsulphonyl optionally substituted by halogen, cyano, carbarmoyl-lower-alkoxy, carbamoyl-lower alkylthio or carbamoyl-lower alkylamino, carbamoyl optionally substituted by lower (cyclo) alkyl, lower alkoxycarbonyl-lower alkyl, benzyloxycarbonyl-lower alkyl or carboxy-lower alkyl or a ring structure of the general formulae Q-X-CO- (a1) Q-X-SO2- (a2) wherein Q represents a 5- or 6-membered ring optionally containing nitrogen, sulphur and/or oxygen and X represents a direct bond or one of the groups -CH2-, -CH2CH2-, -CH=CH-, -NH-, -NHCH2-, -CH2NH-, -CH(NH2)-, -CH2CH2NH-, -C(=NOCH3), -OCH2- and -SCH2-, and wherein further A signifies lower alkyl, hydroxy-lower alkyl,vinyl, cyanovinyl, lower alkoxy, optionally phenyl-substituted lower (cyclo)alkyanoyloxy or (cyclo)alkylsulphonyloxy, optionally lower-(cyclo)alkyl-substituted benzoyloxy or phenyl-sulphonyloxy, a residue -S-Het or -S-CH2-Het, wherein Het represents a 5- or 6-membered heterocycle containing nitrogen, sulphur and/or oxygen, or a residue -CH2-L, wherein L represents optionally phenyl-substituted lower (cyclo)alkanoyloxy or (cyclo)alkylsulphonyloxy, optionally lower (cyclo)alkyl-substituted benzoyloxy or phenyl-sulphonyloxy, carbamoyloxy, lower (cyclo)alkoxycarbonyl, carboxy, azido, amino, lower (cyclo)alkanoylamino, lower (cyclo)alkylsulphonylamino, lower (cyclo)alkylamino, di-lower (cyclo)alkylamino, a 5- or 6-membered ring bonded to a nitrogen atom or a residue -S-Het or -S-CH2-Het, wherein Het has the above significance, and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds. A process for the manufacture of the Beta-lactams described above as well as intermediates occurring therein are also described, as are corresponding medicaments. The products have Beta-lactamase inhibiting properties and are useful in the control of Beta-lactamase-forming pathogens in combination with Beta-lactam antibiotics. They also exhibit antibacterial activity of their own and can accordingly be used themselves in the control of infectious diseases. |
| priorityDate | 1995-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 476.