| abstract |
An oxygen-containing heterocyclic derivative represented by general formula (I), a salt thereof, a solvate thereof or a hydrate thereof: wherein R1 represents hydrogen, A, B, etc., (wherein R8 represents C1-20 alkyl, aryl, etc); R2, R4 and R6 represent each hydrogen, C1-5 alkyl, etc.; R3 and R5 represent each hydrogen, C1-20 alkyl, etc.; R7 represents hydrogen, C, etc. (wherein R9 represents C1-10 alkyl); A represents C1-3 alkylene; and n is 0 or 1, The derivative, which has a potent inhibitory effect on a cysteine protease and is excellent in oral absorbability, tissue transmigration properties and cell membrane-permeability, is useful as a remedy for apoplexy, Alzheimer's diseases, etc. |