http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-387896-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8411a94a2d824bdf348bf40baafdb7d6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 |
| filingDate | 1996-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bf31b9e571b7d94811942810b365f47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a13574a63dd03f54f8c5a9a70030037d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fbcc569d79a870efb0e711874dd09bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d484eb5107ee89e9b2600c9048eb7f61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9165dcbfeca1be7bb28361d2f732d2d |
| publicationDate | 2000-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-387896-B |
| titleOfInvention | Novel dipeptide and tripeptide mimic compounds for treating Parkinson's disease |
| abstract | The invention relates to a protodrug made of L-dopa in coupled with D-phenylglycine or D-p-hydroxyphenylglycine and the dipeptides thereof that is capable of enhancing the oral bioavailablity of the protodrug and delaying the internal metabolic rate of decarboxylation for the L-dopa to prolong its half-life. In the experimental animal model of anti-Parkinson's disease, compound 2d can mitigate the rotation behavior of the rat with damaged gray matter of the brain that is stimulated by (+)toluene-iso-propylamine. The compound 2d has an anti-Parkinson's disease activity equivalent to L-dopa and does not cause the contraction of the pulmonary artery and vasa deferens, indicating that no dopamine-like side effect such as hypertension leading cardiovascular diseases. Such drug is useful in the treatment of patients suffered from Parkinson's disease with hypertension. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021072958-A1 |
| priorityDate | 1996-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.