| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-911 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-185 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P11-00 |
| filingDate |
1995-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bc50189a995a701132c62effe1c947c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0df5d77a37d0f737be9398fb77ad159
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d93ebc855a798a4d59798c9e3148764 |
| publicationDate |
2000-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-384310-B |
| titleOfInvention |
Bioconversion process for the synthesis of transhydroxy sulfone |
| abstract |
There is disclosed a novel microbial bioconversion process for the synthesis of a trans-hydroxy sulfone intermediate, which is the precursor to topical carbonic anhydrase inhibitors (TCAI's). TCAI's are effective in the treatment of glaucoma and ocular hypertension. The bioconversion process is carried out in the presence of the microorganism Rhodotorula rubra, or Rhodotorula piliminae and results in a trans-hydroxy sulfone which exhibits a diastereomeric excess of greater than 95%. |
| priorityDate |
1994-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |