http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-364902-B

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filingDate 1992-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84db334a678a10ed82411a9e0e442c03
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publicationDate 1999-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber TW-364902-B
titleOfInvention Process for the preparation of diacetylrhein
abstract The present invention provides a process for the preparation of diacetylrhein which is substantially free of aloe-emodin components, wherein (A) rhein-9-anthrone-8-glucoside containing aloe-emodin components is subjected to a liquid-liquid partitioning of the compounds obtained is carried out between a polar organic solvent which is only partly miscible with water and an aqueous phase, (B) the rhein-9-anthrone-8-glucoside contained after the partitioning in the aqueous phase is oxidized to rhein-8-glucoside, (C) the glucose residue in the 9-position of the rhein-8-glucoside is split off in an acidic medium and (D) the rhein obtained is acetylated and the diacetylrhein recovered. The present invention is also concerned with diacetylrhein obtainable by this process and with pharmaceutical compositions containing it.
priorityDate 1991-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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