| abstract |
A quinazoline derivative of the formula: (I) in which (symbol) represents a single or double bond; R1 is hydrogen or C1-C4-alkyl; Y is single bond or C1-C6-alkylene; A is (I) -CyA-(R2)l, or (ii) -O-R0 or -S(O)p-R0; in which R0 is hydrogen, C1-C4-alkyl, hydroxy-C1-C4-alkyl or -CyA-(R2)l; p is 0-2; CyA is carbocyclic mono-ring of 3-7 membered, saturated, or benzene ring; (2) heterocyclic mono-ring of 5-6 membered containing one nitrogen, unsaturated; (3) heterocyclic mono-ring of 5-6 membered ontaining one nitrogen and one oxygen, unsaturated; (4) heterocyclic mono-ring of 5-6 membered containing one sulfur, unsaturated, or (5) heterocyclic mono-ring of 5-6 membered containing one oxygen, unsaturated, or fully saturated; R2 is (1) hydrogen, (2) C1-C4-alkyl, (3) C1-C4-alkoxy, (4) -COOR5, in which R5 is hydrogen or C1-C4-alkyl, (5) -NR6R7, in which R6 and R7 independently are hydrogen or C1-C4-alkyl, (6) -SO2NR6R7, in which R6 and R7 are as hereinbefore defined, (7) halogen, (8) trifluoromethyl, (9) nitro or (10) trifluoromethoxy; Z is single bond, methylene, ethylene, vinylene or ethynylene. |