http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-315412-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_152983e1f78f4b093cdd0190f7fcae0a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483 |
| filingDate | 1994-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0b717860ac37feff4618b2a5ad1378f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5b846b385ff06018b4af5544fb4540a |
| publicationDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-315412-B |
| titleOfInvention | A method for detecting antimicrobial compounds by changes in electrical parameters |
| abstract | An aspect of this invention relates to a method for determining the possible presence of an antimicrobial compound in a sample. By "antimicrobial compound" is meant any compound (an antibiotic or otherwise) which is capable of inhibiting the growth of abacterium or a fungus. The method includes the steps of: (i) adding the sample to a culture medium; (ii) growing a microorganism, e.g, a bacterium or fungus (spores or cells), in the culture medium, the growth of the microorganism being susceptible to inhibition by the compound; (iii) measuring an electrical parameter, e.g., conductance, impedance or capacitance, of the culture medium overa period of time; (iv) determining a first time point (detection time, or "DT") at which an accelerating change of the electrical parameter occurs, the change resulting from the growth of the microorganism; and (v) comparing the first time point with a plurality of time points to determine the possible presence of the compound. Each of the plurality of time points is determined in a manner identical to that in which the first time point is determined except that the compound is present in the culture medium at a known concentration, and, further, a relationship exists between the plurality of time points and their corresponding concentrations. The antimicrobial compound-detecting method can be used to detect penicillin G at a concentration as low as 0.00016 IU/ml, which is about 30 times more sensitive than several currently used methods. In addition, the measurement of the electrical parameter is fully automatic, and multiple samples (e.g., 120 or 240) can be analyzed simultaneously. Other features and advantages of the present invention will be apparent from the following drawings and description of the preferred embodiments, and also from the appending claims. |
| priorityDate | 1994-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.