http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-315368-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1470af2d007afa44390c8c9cfbaff5f1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 1996-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e9211e698563a678c1a1b30e66bdda8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_731888a4b1369eaabeeaba70235a2c0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64cbd9b123b26957650e5985a04b72c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26d5946f355543ddd636d4854c2542a5 |
| publicationDate | 1997-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-315368-B |
| titleOfInvention | Method for preparing anti-fungal Fluconazole and salt thereof |
| abstract | A method for preparing Fluconazole and pharmaceutically acceptable thereof comprising the steps of: (1) acylating 1,3-difluorobenzene (DFB) with chloroacetyl chloride to give 2-chloro-2',4'-difluoroacetophenone (CAP); (2) undergoing nitro-alkylation substitution by reacting CAP with 4-amino-4H-1,2,4-triazole to give 2-(1H-1,2,4-triazolo-1-yl)-2', 4'-difluoroacetophenone salt (TAAP-salt); (3) removing the amino groups of TAAP-salt by acid; (4) conducting epoxidation-ring-opening reaction of TAAP in a suitable aqueous solvent to give Fluconazole; and (5) optionally converting Fluconazole into a pharmaceutically acceptable salt. |
| priorityDate | 1996-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.