http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-218894-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dc8916cad43c18d61ff11ce60026761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c6301739f7fe743f8818bc03bc6aec5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efbea096cc0f853aee75cc55fb8739c7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-66 |
| filingDate | 1993-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17df006aa9b72fde473b4f8e2c42cb2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6eff770f2e5be9870b10d779ed26a35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d39debe1bc4750de3aaf8d2c91063b98 |
| publicationDate | 1994-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-218894-B |
| titleOfInvention | Antibiotic compound malbranicin and its production |
| abstract | Malbranicin is produced by a thermophilic fungi named malbranchea cinnamomea (Lib.) Van Oorschot & de IIoog TAIM14T54 isolated from the farm soil in Tang-sui of Taiwan. This compound was isolated from the ethyl acetate extracts of culture filtrates and mycelia by silica gel column chromatography. Fermentation was carried out at 30-50xC for 2-5 days in YpSs liquid medium, on a shaking machine. Malbranicin is a neutral compound, found as yellow needle shaped crystals in methanol, mp 112-114 C;[`]-18xC (c0.1, CH3OH); max(CH3OH) 258 and 360 nm; IR 1700,1680,1645 CM-1, has the molecular formula C11H12O4 estimated from HRELMS (m/z 208.0735 [M+]) and confirmed by elemental analysis. The chemical structure of the compound was elucidated as 6-(1-acetylethyl), 2-methoxyl-2,5-cyclo- -hexadiene-1, 4-dione from the spectrum of 1II-NMR, 13C-NMR and 13C-1H COSY, and confirmed by the single crystal x-ray structure analysis of its acetate derivative of dihydromalbranicin. The MIC values of this compound designated is active to many Gram (+) bacteria and some fungi. The IC50 values of this compound designated that malbranicin is cytotoxic to some tumor cell lines. |
| priorityDate | 1993-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.