http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-213463-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3493d28336d6fb788a5daa0bda063bb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 |
| filingDate | 1992-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16a7b0d410ce8faf43cacb3f9509cf41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fccafae035dcaef1af6328c3088816a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_741f459d03376b5c4dbae2ddb9cad6d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4f8e21850b40cb083b8b8fddf422f50 |
| publicationDate | 1993-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-213463-B |
| titleOfInvention | Production method of 3-substituted-naphthylene[1,8-de] triazole[3,4-b][1,3]thiazine derivatives and their medical usage |
| abstract | A production method of 3-substituted-naphthylene[1,8-de]triazole[3,4-b][1,3]thiazine derivatives of the following formula (I) in which R is hydrogen, C1-C7 alkyl, C1-C3 haloalkyl with 1-3 halogen substituted group, aryl group, hydroxyl group, thiol group; comprising: 1) dehydrating 1-amino-8-sulfo-naphthalene to form 2-hydrogen-naphthylene[1,8-cd]isothiazolyl-1,1-dioxy; 2) reducing the 2-hydrogen-naphthylene[1,8-cd]isothiazolyl-1,1-dioxy to obtain 1-amino-8-naphthyl mercapto; 3) letting the 1-amino-8-naphthyl mercapto react with carbon disulfide to undergo cyclization and to obtain naphtthylene[1,8-de][1,3]-thiazine-2(3hydrogen)-thioxo intermediate; 4) letting the intermediate react with hydrated hydrazine to obtain 2-hydrazino-naphthylene[1,8-de][1,3]thiazine; 5) letting the 2-hydrazino-naphthylene[1,8-de][1,3]thiazine react with reactants capable of forming the R group to undergo cyclo-condensation and to obtain 3-substituted-naphthylene[1,8-de][1,2,4]triazole[3,4-b][1,3]thiazine(I). |
| priorityDate | 1992-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 149.