| abstract |
The invention belongs to the field of medicine, and relates to a class of substituted aza five-membered ring compounds and their application in medicine. Specifically, the present invention relates to compounds represented by formula (I), or stereoisomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, Metabolites, esters, pharmaceutically acceptable salts or prodrugs; also related to pharmaceutical compositions comprising the compounds and methods of use and use thereof. In particular, the compounds described in the present invention are PDE4 inhibitors for the treatment of PDE4-related diseases such as atopic dermatitis (AD) or chronic obstructive pulmonary disease (COPD). |