| abstract |
The present invention provides a quinazoline compound, preparation and use thereof, and specifically relates to a compound of formula (I), or isomers, hydrates, solvates, pharmaceutically acceptable salts and prodrugs thereof, and the preparation method thereof and the use thereof in the manufacture of a drug as tyrosine kinase inhibitors. The compound of the present invention has good inhibitory activity on EGFR and HER2 kinase, and at the same time exhibits excellent performance of penetrating the blood-brain barrier. |