| abstract |
The invention discloses an antibody targeting EpCAM and a preparation method and application thereof. The antibody of the target EpCAM includes VL and/or VH, and the VH includes the VH CDR1 shown in the amino acid sequence of SEQ ID NO: 5, and the VH shown in the amino acid sequence of SEQ ID NO: 6 CDR2, and/or, the VH CDR3 shown in the amino acid sequence of SEQ ID NO: 7; the VL includes the VL CDR1 shown in the amino acid sequence of SEQ ID NO: 8, as shown in SEQ ID NO: 9 VL CDR2 shown in the amino acid sequence of SEQ ID NO: 10, and/or VL CDR3 shown in the amino acid sequence of SEQ ID NO: 10. The present invention overcomes the defects of antibodies against EpCAM in the field, and provides an antibody with a fully human sequence, high affinity, and cross-species binding to cynomolgus monkey antigens, and a preparation method and application thereof. |