| abstract |
The present disclosure provides modulators of T-cell activity, methods of making, and methods of use thereof. In some embodiments, the modulators provided herein comprise novel PD-L1 antibodies. In other embodiments, the modulators provided herein comprise multifunctional polypeptides comprising an extracellular binding domain of a CD80 polypeptide, a disease-associated antigen-binding domain, and an Fc domain. The present disclosure also provides pharmaceutical compositions comprising such modulators and methods for use in the treatment of cancer, infectious diseases, and inflammatory diseases. |