| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9bdd487daff4ac3fa5b19830e61726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4716 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_733712619d667b628c0ad9ef5dc7aba0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef686ea7bd79a90670213a720ea6fe0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06928bfb8ab11b20de2716a4a50cbbf4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7914b8de281e3659addfb91a7777cd98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaf24a75f4ea1158df03ff3815926425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ef6280970079999136a600ddfe9dfe0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecd7f0cd5f57998f9ce438a35b39b22b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6589b6dfcc71a5ff895869e82a42256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c77978d4d9a7aedf9d5db73bdbb6aeb |
| publicationDate |
2021-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-202130654-A |
| titleOfInvention |
Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| abstract |
The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with a mutation in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF isoform 5 protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF isoform 5 protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss. |
| priorityDate |
2019-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |