| abstract |
The present invention relates to a nitrogen-containing polycyclic derivative inhibitor, a preparation method therefor and the application thereof. In particular, the present invention relates to a compound represented by the general formula (I), a preparation method therefor, and a pharmaceutical composition containing the compound, and the use thereof as a kinase inhibitor, especially as a receptor tyrosine kinase inhibitor (TKI). More specifically, its use as an EGFR or HER2 inhibitor in the treatment of cancer, inflammation, chronic liver disease, diabetes, cardiovascular disease and AIDS and other related diseases. Wherein, each substituent in the general formula (I) has the same definition as in the specification. |