| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872dd7cd609eb2a937dcfd303d521798
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b99e2c723498fb91a5f3957b9560a17a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2537-165 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16C20-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf458cc3e9dc69bb42dd862d5b44d834
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0b85032b1ab0928f40f12c546194ac0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b96a5a31ca433bc32906dbc97c0e5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7747258f8c38eaff46c5ebfd4853edba |
| publicationDate |
2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-202126806-A |
| titleOfInvention |
Production method |
| abstract |
The invention relates to a method of predicting production stability and/or production instability of a clonal cell line, the method comprising the steps of (a) growing two or more clonal cell lines in separate cell cultures (b) karyotyping the cells in each cell culture; and (c) deriving a genomic instability value from the karyotyping of step (b). The invention also relates to methods of selecting a cell line which expresses a therapeutic protein and method of selecting a high-titre producing clonal cell line for large scale therapeutic protein production. |
| priorityDate |
2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |