| abstract |
The subject of the present invention is to provide a high-efficiency manufacturing method for peptides, and to provide a method for manufacturing peptides, which includes the following steps (1) and (2): (1) N-protected amino acid or N-protected Steps of mixing peptide and carboxylic acid halide represented by formula (I): (In the formula, X represents a halogen atom, R 1 , R 2 and R 3 independently represent an aliphatic hydrocarbon group which may have a substituent, and the total number of carbon atoms in R 1 , R 2 and R 3 is 3 to 40); and ( 2) The step of mixing the product obtained in step (1) with C-protected amino acid or C-protected peptide. |