| abstract |
The invention relates to alkyne derivatives, their preparation methods and their application in medicine. Specifically, the present invention relates to alkyne derivatives represented by formula (I), their preparation methods and their pharmaceutically acceptable salts, and their use as therapeutic agents, especially phosphatidylinositol-3-kinase γ (PI3Kγ) The use of the inhibitor, wherein the definition of each substituent in formula (I) is the same as the definition in the specification. |