http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-202100752-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22cfb567db75fc288e9fb93aacdf08b3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-72 |
| filingDate | 2020-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23b18e7d162ff0741cd3a56085475318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2d6edde9008c88cefff29ba53daf34e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56972274f27e75fc98c83543d430564a |
| publicationDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-202100752-A |
| titleOfInvention | Method for predicting the effectiveness of the treatment of hemoglobinopathies |
| abstract | The present application relates to a method for treating hemoglobinopathy in an individual, including: (a) an evaluation step, which includes evaluating the ability of the first population of modified CD34-positive hematopoietic stem cells/progenitor cells to produce the desired level of [gamma]- globin or fetal hemoglobin, wherein the modified CD34-positive HSPCs of the first population are derived from an individual and have been modified to reduce BCL11A function; and (b) a treatment step comprising administering to the individual a second population of modified CD34-positive HSPC, which is derived from the individual and modified to reduce BCL11A function. At the same time, this application also relates to a method for treating hemoglobinopathy in an individual, a method for selecting an individual suffering from hemoglobinopathy for treatment with modified CD34-positive HSPCs of the second population, and a method for determining whether an individual suffering from hemoglobinopathy is suitable for the treatment with modified CD34-positive HSPCs derived from the individual and modified to reduce the function of BCL11A in the second population. |
| priorityDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 744.