| abstract |
The present disclosure relates to a bifunctional fusion protein and its medical use. Specifically, the present disclosure relates to a bifunctional fusion protein comprising a SIRP[gamma] peptide variant and an anti-human PD-L1 antibody, a SIRP[gamma] peptide variant, and the medicinal use thereof. The bifunctional fusion protein according to the present disclosure can specifically bind to PD-L1 and CD47, and block the binding of PD-L1 or CD47 to its receptor or ligand. At the same time, the present disclosure also provides the preparation and use of the bifunctional fusion protein and the treatment of cancer and immune-related diseases. |