| abstract |
The subject of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules that change antigen-binding activity in response to the concentration of unnatural compounds, a database containing a plurality of different antigen-binding molecules, and medicines containing the antigen-binding molecules Composition, method of screening the antigen-binding molecule, and manufacturing method thereof. The inventors of the present case discovered that by creating antigen-binding domains or antigen-binding molecules containing antigen-binding domains that change the binding activity to antigens depending on the concentration of low-molecular-weight compounds, they can further create a plurality of different antigen-binding domains. Domains or a database containing antigen binding domains, and using the database can solve the above-mentioned problems. By using the antigen-binding molecule of the present invention, the target tissue can be specifically treated for various diseases caused by the target tissue. |