| abstract |
The present invention relates to nitrogen-containing heteroaryl derivative regulators, preparation methods and application thereof. In particular, the present invention relates to compounds represented by the general formula (I), their preparation methods and pharmaceutical compositions containing the compounds, and their use as protein tyrosine phosphatase-2C (SHP2) inhibitors for the treatment of diseases or symptoms such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and ncolon cancer thereof. wherein each substituent in the general formula (I) is the same as defined in the specification. |