| abstract |
Efisoxime (TH-302) or its analogues have specific inhibitory effect on cells with specific gene mutations, specifically cells with damaged DNA repair, the cells or tissues have at least BRCA1, BRCA2, FANCD1, FANCD2 , ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2 , ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP or ERCC5, one or more gene mutations. For this purpose, the medical use of efoxamide (TH-302) or its analogues in the treatment of tumors and cancer diseases of cancer patients with the above-mentioned specific gene mutations is provided. |