| abstract |
Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX 1 nGGGX 2 nGGTX 3 nA (SEQ ID No:1), in which each of X 1 nand X 2 nare independently G, C, or absent, and X 3 nis T or C, or L-(G) n n-L’, in which n is an integer of 5-9 inclusive, and L and L’ are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence. |