http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-202000204-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e43b4ca6b41ce9f54c9a895d474c81a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 |
| filingDate | 2019-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa2bf8f9817180b58526734ada60279a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ae49e35fec2d51f433c63f36bf9253 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48290b304d816e02730a8a55050b3f81 |
| publicationDate | 2020-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-202000204-A |
| titleOfInvention | Pemetrexed sodium injection solution preparation and manufacturing method thereof |
| abstract | In the medical field, compared with freeze-dried preparations, RTU (Ready-to-use, ready-to-use) preparations that require no complicated dissolution steps and can be diluted and administered immediately in a highly convenient solution form are required. The object of the present invention is to provide a solution preparation for injection containing pemetrexed that suppresses the formation of similar substances and inhibits the coloration of the solution during storage. According to the present invention, there is provided a method for manufacturing an injectable solution preparation, which is a method for manufacturing an injectable solution preparation containing pemetrexed disodium as an active ingredient, the method comprising: (1) using pemetrexed disodium A step of preparing a solution for injection using raw materials, and (2) a step of filling the above-mentioned solution for injection into a container for a preparation, and tightly sealing it with a rubber stopper in an atmosphere in which the oxygen concentration of the void portion is 1% by volume or less, and The above-mentioned raw material contains a component with a relative retention time (RRT) of 0.41±0.03 using pemetrexed retention time (RT) as an indicator in HPLC analysis of 0.10% or less. |
| priorityDate | 2018-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.