| abstract |
The present invention provides a combination drug comprising two, three or more independent compounds, wherein each compound is a phosphodiesterase inhibitor, an adenosine receptor antagonist, a calcium channel blocker, and histamine H 1- Receptor agonist, histamine H 2 -receptor agonist, histamine H 3 -receptor antagonist or β 2 -adrenergic receptor agonist, or one or more of the active compounds is rich in isotopes (isotopes are not enriched in Less than 50%). The present invention also provides a combination medicine and method of using for treating, preventing or ameliorating cardiovascular disease in a subject, which comprises administering a combination medicine of two, three or four independent compounds to a subject in need, each of which Compounds are phosphodiesterase inhibitor, adenosine receptor antagonist, calcium channel blocker, histamine H 1 -receptor agonist, histamine H 2 -receptor agonist, histamine H 3 -receptor Antagonist or β 2 -adrenergic receptor agonist. |