http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201940491-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e43b4ca6b41ce9f54c9a895d474c81a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-05 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 |
| filingDate | 2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6910607caceb5d62de75793399f97cf5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a11b8485b39cda749bfb485d18b250b3 |
| publicationDate | 2019-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201940491-A |
| titleOfInvention | Production method of bortezomib crystal |
| abstract | Bortezomib has a variety of crystalline forms. Pharmaceutical raw materials are required to be in a single crystalline form in order to achieve uniform physical properties and quality such as solubility. However, the type II crystal and the N-type crystalline solvent and the crystallization temperature of bortezomib are almost the same. It is highly possible that these two crystal forms are mixed, and it is very difficult to obtain one of the crystal forms stably. Therefore, development of a method for selectively and stably producing a type II crystal or an N-type crystal of bortezomib is necessary. The present invention provides selectively and stably obtaining high-yield by controlling the water content in the crystallization system, or the water content and the crystallization temperature in a specific range during the operation of obtaining crystals of bortezomib. Production method of bortezomib type II crystal or N type crystal. |
| priorityDate | 2018-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.