| abstract |
The present invention discloses a 2-aminopyrimidine-substituted 2 H -indazole compound of formula (I) (wherein R 1 is hydrogen) and its prodrug (where R 1 is a group that can be metabolized under physiological conditions). As cyclin-dependent kinase (CDK) and cell proliferation inhibitor, as well as its therapeutic use and preparation method. These compounds and their pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions can be used to treat diseases and conditions related to the activity of cyclin-dependent kinases, and specifically CDK4 / 6, including (but not Limited to) various cancers and inflammation related diseases or conditions. |