| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c58a362565a0616bcc3901fcbf9643de |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b329215f7d65703f4acd1cc2c267819
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c431005a64e3d66871a94fe129dbeff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26ec10aa0c4424afd9408b9d1a400fd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1f48eab88803b44ec228b146c1171fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a902db7ae37d0daaadd9a3f37e444bca |
| publicationDate |
2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201932601-A |
| titleOfInvention |
Method for enhancing the transcriptional regulation ability of SUPT4H in a nucleotide repeat sequence of a cell |
| abstract |
The invention provides a method for regulating a gene containing a nucleotide repeat sequence expansion cell in a cell, which comprises: inhibiting the biological activity of SPT4 or SUPT4H; and regulating the formation of R-loops. The inhibition step can effectively reduce the expression of the nucleotide repeat expansion gene and the regulation step can further enhance the effect of the inhibition step. The inhibition step and the regulation step interfere with the ability of RNA polymerase Ⅱ to transcribe the DNA template through the R-loops generated by the nucleotide repeat sequence, thereby achieving the purpose of regulating gene expression. |
| priorityDate |
2018-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |