| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bd7a45a343acd10e3f5d8775dda2157 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2017-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6793a8a77527f849eadaf9f8f91940dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15155cf3689cde410461c9d7218b13b4 |
| publicationDate |
2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201932492-A |
| titleOfInvention |
Inhibition of SCUBE2, a novel VEGFR2 co-receptor, inhibits tumor angiogenesis |
| abstract |
The present invention discloses an isolated SCUBE2 antibody or a binding fragment thereof. The SCUBE2 antibody comprises an antigen binding region that specifically binds to the target domain of SCUBE2 (SEQ ID NO: 66) and is capable of inhibiting VEGF-induced angiogenesis. The target domain is selected from the following structural regions: EGF-like motifs of SCUBE2 (SEQ ID NO: 66) 4 to 6 (aa 175 to 323), spacer region (aa441) To 659), or the first cys-rich motif (aa668 to 725). The SCUBE2 antibody or a binding fragment thereof can be used for treating a disease associated with VEGF-induced angiogenesis in an individual in need thereof, for example, by suppressing tumor angiogenesis and achieving the purpose of reducing cancer cell growth. |
| priorityDate |
2016-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |