| abstract |
This application relates to anti-4-1BB antibodies, their antigen-binding fragments and their medical uses. Further, the present application relates to chimeric antibodies, humanized antibodies containing the CDR region of the anti-4-1BB antibody, and pharmaceutical compositions containing the human anti-4-1BB antibody or antigen-binding fragment thereof, and their use as anticancer drugs use. In particular, the present application relates to the use of a humanized anti-4-1BB antibody in the preparation of a medicament for treating a 4-1BB-mediated disease or disorder. |