| abstract |
The invention relates to a fusion protein, a method for preparing the fusion protein, and a method for using the fusion protein, wherein the fusion protein comprises: a single domain antibody (sdAb) or a functional variant thereof, and a cytosine deaminase (CD) protein or a Functional variants, both of which are optionally linked via a linker peptide. The fusion protein of the present invention also has CD activity. The invention also relates to a pharmaceutical composition or formulation comprising said fusion protein and a pharmaceutically acceptable excipient, and the medical use of these fusion proteins. |