| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-66 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2018-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c27df60a90700ed061a89a1c1f12105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce6eeb88448a415d62e4b2e03c509f0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d0216d9d4f5072122ec5bcff0ba0aab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac283fe20eaeaf0f131bd4c3dbbf86cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_632105c1735845c86984df123641f00d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc08cc2fa36f7eca484cd16b83b4bccf |
| publicationDate |
2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201932142-A |
| titleOfInvention |
Method for producing multispecific antibodies from monospecific antibodies |
| abstract |
This article reports a method for generating multispecific antibodies by a half-antibody exchange reaction. The half-antibody exchange reaction is performed between two 2 / 3-IgGs, and half of the two 2 / 3-IgGs are asymmetric Perturbation mutations and lose stability, thereby promoting the production of full-length bispecific antibodies that are correctly assembled. This method can be performed in the absence of a reducing agent and does not require the presence of hinge disulfide bonds in the original 2 / 3-IgG. |
| priorityDate |
2017-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |