| abstract |
An object of the present invention is to provide a lipocalin-type prostaglandin D2 synthetase (L-PGDS) production promoter, and more specifically, the ischemia-inducible is derived from or dedifferentiated from an outer cell L-PGDS production promoters are provided in potential stem cells (iSC).nn n n In the present invention, a substance having an effect of promoting L-PGDS production was confirmed to be contained in extracts of inflammatory tissues inoculated with vaccinia virus. LPGDS production promoters are highly useful for diseases where the effect due to the promotion of L-PGDS expression is expected, that is, as prevention of cerebrovascular disorders such as cerebral infarction, cognitive disorders such as Alzheimer's disease, or sleep disorders, Treatment or relapse prevention drugs are highly useful. |