| abstract |
The invention discloses the application of 5α-andro-3-3,5,6β-triol and its analogs, deuterates or pharmaceutically acceptable salts thereof in the preparation of a medicament for treating cerebral small vessel disease in patients. The cerebral small vessel disease is preferably a cerebral microbleed. The cerebral hemorrhage is spontaneous cerebral hemorrhage, drug-related cerebral hemorrhage, or traumatic cerebral hemorrhage. The present invention confirms that these compounds significantly enhance the clearance of extravascular hemoglobin and are therefore useful in the treatment of cerebrovascular diseases. |