| abstract |
The present invention provides an entecavir antiviral prodrug nucleoside cyclic phosphate compound based on liver specific delivery technology (liver delivery) (LSD) and its application. Specifically, the present invention provides compounds of formula I and isomers thereof, pharmaceutically acceptable salts, hydrates, solvates, and corresponding pharmaceutical compositions. The present invention also provides the use of the compound of the present invention alone or in combination with other antiviral drugs in antivirus, especially in the application of anti-hepatitis B virus (HBV). |