| abstract |
The invention relates to the field of ATG4-related disorders. More specifically, the invention relates to a method of treating an ATG4B-related disorder, comprising the step of administering an effective dose of ticonazole to an individual. The invention also relates to a method of increasing the sensitivity of a subject to cancer treatment, comprising inhibiting ATG4B activity in a cell, the method comprising administering to the subject an effective dose of ticonazole. The present invention also relates to a method for enhancing or inducing a cancer cell to respond to one or more of the groups consisting of, but not limited to, cytotoxicity, chemical sensitivity, or starvation sensitivity, the method comprising administering to a subject by inhibiting ATG4B activity An effective amount of ticonazole is administered. |