http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-201922749-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bd7a45a343acd10e3f5d8775dda2157 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73c00a6da27d5874a581dd8afd1f8473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76763eb1a42e7e84643dcf51f457e153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95daa5c65d33923a732be4b51578968a |
| publicationDate | 2019-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-201922749-A |
| titleOfInvention | Mixture of bis(hydroxymethyl)pyrrolopyridazine, preparation method and use thereof |
| abstract | The present disclosure relates to novel bi-functional compounds and their use in the treatment and / or prevention of cancer. The present disclosure has a bifunctional compound having a structure of formula (I), Where A is a 6-10 member unsaturated carbocyclic ring with or without substituents; R 1 is an alkyl group substituted with or without halogen, -OR, -OAc, -OSO 2 R, or -OCONHR, where R is Hydrogen, alkyl, cycloalkyl or aryl; R 2 is hydrogen, alkyl, cycloalkyl, aryl or heteroaryl; R 3 is -NR A R B , -NHPhR C , mono or disaccharide, Either an amino acid group or -NR A R B combined to form an aniline or cycloalkylamine with or without substituents selected from morpholine, pyrrolidine, piperidine, 1-substituted piperidine A group of 1,4'-bipiperidine and 4'-substituted 4,4'-bipiperidine; wherein the substituents of piperazine and 4,4'-bipiperidine are alkyl groups, -(CH 2 ) n CONH (CH 2 ) m NR A R B , where n and m are each an integer between 1 and 5, and R A and R B are each H or C 1 -C 6 alkyl; R C is hydrogen, halogen, alkoxy, -CH 2 OH, -NHCOR a , -NHC (O) OR a , or alkyl, alkenyl, alkynyl, heterocyclic or aromatic with or without substituents And R a is C 1-6 alkyl or aryl; and optionally, the aryl or heteroaryl has at least one substituent, wherein The at least one substituent is selected from the group consisting of C 1-6 alkyl, alkoxy, halogen, cyano, nitro, -NH 2 , -NHR c , -N (R c ) 2 , cycloalkylamino, methylene A group of dioxy and ethylenedioxy groups, wherein R c is each hydrogen or C 1-10 alkyl. |
| priorityDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.