| abstract |
The present invention relates to polypeptides that bind aggrecan and ADAMTS5 and / or MMP13, and more particularly, to immunoglobulins that include or consist essentially of aggrecan and ADAMTS5 and / or MMP13 Polypeptides (also referred to herein as "polypeptides of the invention" and "immunoglobulins of the invention"). The invention also relates to constructs that include such immunoglobulins (e.g., immunoglobulin single variable domains (ISVD) or polypeptides) and nucleic acids encoding these immunoglobulins or polypeptides (also referred to herein as "the present Invention nucleic acid "); with regard to methods of preparing such immunoglobulins, polypeptides and constructs; with respect to host cells expressing or capable of expressing such immunoglobulins or polypeptides; with respect to compositions, and more particularly with respect to pharmaceutical compositions, It includes such immunoglobulins, polypeptides, constructs, nucleic acids and / or host cells; and uses with respect to immunoglobulins, polypeptides, constructs, nucleic acids, host cells and / or compositions, especially for prevention and / Or therapeutic purpose, such as the preventive and / or therapeutic purpose mentioned herein. From further descriptions herein, other aspects, specific embodiments, advantages and applications of the present invention will become clear. |