| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be67c4f8310f95bf94b15d861ab61dbb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-725
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate |
2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0ec287939f2a22e6fbc5994cb2ad756
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac6c40e1f516aa1293f566f7b74b77e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8325fbcc5e429a1d110cff94f7403c2 |
| publicationDate |
2019-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
TW-201920250-A |
| titleOfInvention |
Method and composition for genetically modifying and expanding lymphocytes and modulating their activity |
| abstract |
The present invention provides methods and compositions for genetically modifying lymphocytes and related methods including genetically modifying T cells and / or NK cells. These methods use non-replicating competent recombinant retroviral particles, which include pseudotyped elements on their surfaces and optionally membrane-bound T-cell activating elements (such as anti-CD3 ), And encodes one or more engineered signaling polypeptides that may include a lymphoproliferative element and / or a chimeric antigen receptor (CAR). Such methods may include contacting the PBMC with a non-replicating competent retroviral particle for different exemplary periods, such as less than 24 hours or less than 15 minutes in some illustrative embodiments. Provides an illustrative chimeric lymphoproliferative element capable of promoting the survival and / or proliferation of T cells or NK cells in culture without the addition of IL-2. In addition, additional regulatory elements are provided, such as inhibitory RNA molecules. |
| priorityDate |
2017-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |